MARINOL significantly improves appetite6

Results from a 6-week, randomized, double-blind, placebo-controlled study of 139 AIDS patients (88 evaluable). Patients used visual analog scales (VAS) to quantify changes in appetite and nausea from baseline.6

• MARINOL has been shown to reduce nausea (-20% vs -7% for placebo, P=0.05).⁶

MARINOL is contraindicated in any patient who has a history of hypersensitivity to any cannabinoid or sesame oil. Warn patients not to drive, operate machinery, or engage in hazardous activity until they establish they can tolerate MARINOL and perform such tasks.⁵

MARINOL should be used with caution in patients with a history of seizure disorder; patients with cardiac disorders; patients with a history of substance abuse (including alcohol abuse or dependence); patients with mania, depression, or schizophrenia (along with careful psychiatric monitoring); patients taking sedatives, hypnotics, or other psychoactive drugs; and in elderly patients, pregnant patients, nursing mothers, or pediatric patients.⁵

The most common adverse effects probably related to MARINOL are dizziness, euphoria, paranoid reaction, somnolence, thinking abnormal, abdominal pain, nausea and vomiting.⁵