
Concentrations of cannabinoid receptors exist in the higher cortical centers
and in the medulla, where the vomiting center is located.
15,16
Serotonin, dopamine, and substance P16
- Key neurotransmitters in the emetic response16
- Endocannabinoids can inhibit their release6,10*

*Based on pharmacologic human and animal models.
MARINOL is indicated for the treatment of nausea/vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetics.14